Riboswitchaptamer

由 H Ge 著作 · 2021 · 被引用 18 次 — Riboswitch sensors are RNA aptamers, i.e., hairpin structures that bind small molecules with high affinity and specificity. Usually, synthetic ...

由 R Micura 著作 · 2020 · 被引用 122 次 — This review aims at juxtaposing common versus distinct structural and functional strategies that are applied by aptamers, riboswitches, ...

由 K Mustafina 著作 · 2019 · 被引用 30 次 — Self-cleaving ribozymes engineered to be activated or inhibited by a small molecule binding to an RNA aptamer inserted within a ribozyme ...

由 MG Mohsen 著作 · 2023 · 被引用 11 次 — Exploiting components of a natural riboswitch to serve as a scaffold for novel aptamer development in vitro and functional validation in cells.

Riboswitches are often conceptually divided into two parts: an aptamer and an expression platform. The aptamer directly binds the small molecule, and the ...

Riboswitches are composed of two domains: the aptamer domain and the expression platform (Figure 1; Tucker & Breaker 2005). The aptamer domain acts as a ...

由 AD Garst 著作 · 2011 · 被引用 404 次 — The sequence of the aptamer domain of the purine riboswitch, one of the simplest aptamers, contains three conserved helical elements (P1, P2, and P3) (Fig. 2A) ...

由 D Antunes 著作 · 2018 · 被引用 37 次 — The structure of a riboswitch includes the aptamer and the expression platform, both of which are connected by the switching sequence. The ...

由 J Richards 著作 · 2021 · 被引用 21 次 — Our discovery that a small riboswitch aptamer that can fold as an H-type pseudoknot can prolong the lifetime of mRNA by acting directly to ...